Most of 12 Bar Blues is about Drugs and Sex...I dont think any of the songs are about his first wife except About Nothing
Desperation #5 - Most of the song was written while in rehab...he was full of detox drugs at the time.
Barbarella - Drugs, how they've controlled his life and his failures.
About Nothing - He was riding in a car with his wife (I believe) and they had a arguement, he got out of the car and ran off into the night. It was something to that effect.
Where's The Man - trying to kick cold turkey
Divider - Drugs, hollywood, probably some junkie chick
Cool Kiss - About a stripper? he used to hang out with...they were too loaded to have sex. He thinks she's dead now
The Date, Jimmy Was a Stimulator, Lady.., Mockingbird Girl....I forget exactly what he said they were about but I'm sure there's a lot of drugs...sex and "some girl" in there.
Opposite Octave Reaction - He had his first orgy when he was 12...this song is about feeling perverted and feeling alienated or something to that effect.
Oh and Son wasn't about Noah. The song was mainly written by someone else (the name escapes me) who had lost a son. It touched Scott because he had already aborted several pregnancies and it was it was a sort of "what could have been" type song for him.